Examining the effects of sex differences in atypical Alzheimer's Disease

 
   Lead Investigator:    Eleni Varelas
   Institution      :    Northwestern University
   E-Mail           :    elenivarelas2018@u.northwestern.edu
   Proposal ID      :    634



   Proposal Description:
   I am interested in learning how the levels of CSF biomarkers differ based on      the sex of patients with atypical AD and also typical AD. There is compelling     literature on why patients with typical AD are predominately females however,     it is not yet known why men are actually favored for atypical AD. I wish to dig   a bit deeper, beyond just acknowledging the sex discrepancies between disease     types, to exploring the CSF levels of p-tau, A??42, and ATI. If this project is   successful, sex may even become a biomarker for diagnosing Alzheimer???s          pathology for patients with an atypical clinical presentation. Also, priceless    knowledge will be gained as to how the biomarkers act and differ between the      sexes.